Working with MCC

The Medicinal Chemistry Center operates under a hybrid collaborative/fee-for-service model.

Collaborative

For projects involving development of novel small molecules, the Medicinal Chemistry Center will work with the collaborator to meet their project aims. Projects of this nature include:

• Development of small molecule probes (attachment of fluorophore, biotin, clickable tether, etc.)
• Hit-to-lead optimization campaigns from validated screening hits
• Rational drug design program
• SAR analysis

Details on the collaboration including potential cost-sharing plans can be discussed at or after the initial meeting.

We recently received a UW2020 award to establish a targeted protein degradation platform to accelerate translational research at UW–Madison. Please contact the MCC Director for more details.

Fee-for-service

For projects generally short in scope with well defined chemistries, the Medicinal Chemistry Center will work with clients in a fee-for-service model to meet their project aims, including:

• Synthesis of known bioactive small molecules from the literature (not commercially available)
• Scale-up synthesis of bioactive small molecules to support animal studies (up to multi-gram scale)
• Sample analysis (ie. NMR, MS, IR, m.p., optical rotation, HPLC purity)

Project involvement may include:

• Limited Pro-bono consulting
• Fee-based laboratory services
• Consultant/Contractor for grant-based activities
• “Core Laboratory” for grant-based programs

Workflow may include:

• Client inquiry
• Review of screen and other relevant project data
• Preparation of a formal or informal project proposal
• Agreement of project scope
• Project commencement
• Project completion

Grant supported projects should provide the following information:

• PI Name and Title
• Affiliation
• ERA Commons Name
• Project Title
• Project Funding Source
• Intended Project Outcome